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Details for Dr. Amanda McCann BA Mod., Micro Ph.D

Position:College Lecturer & Principal Research Investigator AND Conway Investigator
Institution:University College Dublin - CONWAY Institute of Biomolecular and Biomedical Research
Curriculum Vitae:http://www.ucd.ie/conway/cv_8.html
Email:Amanda.McCann@ucd.ie
 
Active Research Topics:
  		• Correlating methylation and transcription activity with RT-PCR analysis
  		• Genetics of bladder cancer
  		• Genomics and proteomics of breast cancer
  		• Molecular Genetics of Breast Cancer
  		• Various Cancer-related Interests
  		• Reversibility of abnormal imprinting phenotypes using demethylation in vitro assays
     
    General Research Interest(s) :
  		• Androgen Independence
  		• Angiogenesis
  		• Apoptosis
  		• Apoptosis Inhibitors
  		• Biomarkers
  		• Bladder
  		• Blood
  		• Breast
  		• Breast Cancer
  		• Cancer Strategies { General }
  		• Cell Cycle Signalling
  		• Chemotherapy
  		• Clinical Studies
  		• Customised Gene Arrays
  		• Differential Gene Expression
  		• DNA Methylation
  		• Drug Design & Synthesis
  		• Enabling Technologies { Other }
  		• Familial
  		• Familial Inheritance
  		• Genomics
  		• Genomics - Various
  		• High Throughput Gene Arrays
  		• Imaging Techniques { Other }
  		• Immunohistochemistry
  		• Mass Spectrometry
  		• Metabolism
  		• Metastasis
  		• Microarrays
  		• Microinjection & Micro Dissection
  		• Polymerase Chain Reaction
  		• Prostate Cancer
  		• Prostate Gland
  		• Proteomics
  		• Real Time Polymerase Chain Reaction
  		• RT-PCR
  		• SNP Analysis
  		• Transcription
  		• Urinary Diseases & Complications
  		• Urinary Organs
     
    Key publications for Dr. Amanda McCann BA Mod., Micro Ph.D:
  		• Alpha-T-catenin (CTNNA3) displays tumour specific monoallelic expression in urothelial carcinoma of the bladder
    M. Meehan, A. Melvin, E. Gallagher, J. Smith, A. M. Goldrick, C. Moss, S. Goossens, M. Harrison, E. Kay, J. Fitzpatrick, P. Dervan and A. M. Cann
    Genes Chromosomes Cancer  2007  Mar  Accession No. 17366617
  		• Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer
    E. Gallagher, A. Mc Goldrick, W. Y. Chung, O. Mc Cormack, M. Harrison, M. Kerin, P. A. Dervan and A. Mc Cann
    Genomics  2006  Apr  Accession No. 16624517
  		• Estrogen receptor beta and breast cancer
    P. J. Balfe, A. H. McCann, H. M. Welch and M. J. Kerin
    Eur J Surg Oncol  Vol:30  Issue:10  Pages:1043-50  2004  Dec  Accession No. 15522549
  		• Elevated expression and altered processing of fibulin-1 protein in human breast cancer
    L. M. Greene, W. O. Twal, M. J. Duffy, E. W. McDermott, A. D. Hill, N. J. O'Higgins, A. H. McCann, P. A. Dervan, W. S. Argraves and W. M. Gallagher
    Br J Cancer  Vol:88  Issue:6  Pages:871-8  2003  Mar  Accession No. 12644824
  		• Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer
    I. S. Pedersen, P. Dervan, A. McGoldrick, M. Harrison, F. Ponchel, V. Speirs, J. D. Isaacs, T. Gorey and A. McCann
    Hum Mol Genet  Vol:11  Issue:12  Pages:1449-53  2002  Jun  Accession No. 12023987
  		• An ecological approach to breastfeeding
    L. B. Tiedje, R. Schiffman, M. Omar, J. Wright, C. Buzzitta, A. McCann and S. Metzger
    Mcn Am J Matern Child Nurs  Vol:27  Issue:3  Pages:154-61; quiz 162  2002  May  Accession No. 12015443
  		• Frequent loss of imprinting of PEG1/MEST in invasive breast cancer
    I. S. Pedersen, P. A. Dervan, D. Broderick, M. Harrison, N. Miller, E. Delany, D. O'Shea, P. Costello, A. McGoldrick, G. Keating, B. Tobin, T. Gorey and A. McCann
    Cancer Res  Vol:59  Issue:21  Pages:5449-51  1999  Nov  Accession No. 10554015
  		• Loss of heterozygosity of the Wilms' tumor suppressor gene (WT1) in in situ and invasive breast carcinoma
    A. Fabre, A. H. McCann, D. O'Shea, D. Broderick, G. Keating, B. Tobin, T. Gorey and P. A. Dervan
    Hum Pathol  Vol:30  Issue:6  Pages:661-5  1999  Jun  Accession No. 10374774
  		• The MAS proto-oncogene is imprinted in human breast tissue
    N. Miller, A. H. McCann, D. O'Connell, I. S. Pedersen, V. Spiers, T. Gorey and P. A. Dervan
    Genomics  Vol:46  Issue:3  Pages:509-12  1997  Dec  Accession No. 9441760
  		• Biallelic expression of the IGF2 gene in human breast disease
    A. H. McCann, N. Miller, A. O'Meara, I. Pedersen, K. Keogh, T. Gorey and P. A. Dervan
    Hum Mol Genet  Vol:5  Issue:8  Pages:1123-7  1996  Aug  Accession No. 8842730
  		• Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status
    A. H. McCann, A. Kirley, D. N. Carney, N. Corbally, H. M. Magee, G. Keating and P. A. Dervan
    Br J Cancer  Vol:71  Issue:5  Pages:981-5  1995  May  Accession No. 7734324
  		• Prognostic significance of microvessel density in lymph node negative breast carcinoma
    P. Costello, A. McCann, D. N. Carney and P. A. Dervan
    Hum Pathol  Vol:26  Issue:11  Pages:1181-4  1995  Nov  Accession No. 7590689
  		• c-erB-2 oncoprotein expression in malignant and nonmalignant breast tissue
    A. McCann, P. A. Johnston, P. A. Dervan, W. J. Gullick and D. N. Carney
    Ir J Med Sci  Vol:158  Issue:6  Pages:137-40  1989  Jun  Accession No. 2570047
  		• c-erbB-2 oncoprotein expression in primary human tumors
    A. McCann, P. A. Dervan, P. A. Johnston, W. J. Gullick and D. N. Carney
    Cancer  Vol:65  Issue:1  Pages:88-92  1990  Jan  Accession No. 2403483
  		• Non-M CK--a practical measure of creatine kinase isoenzymes in cancer patients
    P. G. McGing, M. Teeling, A. McCann, F. Kyne and D. N. Carney
    Clin Chim Acta  Vol:187  Issue:3  Pages:309-15  1990  Mar  Accession No. 2323070
  		• Prognostic significance of c-erbB-2 and estrogen receptor status in human breast cancer
    A. H. McCann, P. A. Dervan, M. O'Regan, M. B. Codd, W. J. Gullick, B. M. Tobin and D. N. Carney
    Cancer Res  Vol:51  Issue:12  Pages:3296-303  1991  Jun  Accession No. 1674898
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