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Details for Dr. Orla M Sheils Ph.D, FAMLS

Position:Senior Lecturer in Molecular Pathology AND IMM Investigator
Institution:Trinity College Dublin - Institute of Molecular Medicine
Email:osheils@tcd.ie
 
Active Research Topics:
  		• Biomarkers of disease
  		• Cervical Cancer
  		• Development of array technologies
  		• Molecular pathology
  		• Prostate cancer
     
    General Research Interest(s) :
  		• Biomarkers
  		• Blood
  		• Cancer Strategies { General }
  		• Clinical Studies
  		• Colon
  		• Colorectal & Oesophageal Cancer
  		• Customised Gene Arrays
  		• Diagnostics
  		• Differential Gene Expression
  		• Enabling Technologies { Other }
  		• Epidemiology
  		• Genetic Studies { General }
  		• Genomics
  		• Gynaecological Cancer
  		• High Throughput Gene Arrays
  		• Imaging Techniques { Other }
  		• Immunohistochemistry
  		• Metabolism
  		• Microarrays
  		• Polymerase Chain Reaction
  		• Potential Therapeutics or Drug Targets
  		• Prostate Cancer
  		• Prostate Gland
  		• Proteomics
  		• Reproductive Diseases & Complications
  		• Reproductive Organs
  		• Thyroid & Parathyroid Thymus
  		• Uterus
     
    Key publications for Dr. Orla M Sheils Ph.D, FAMLS:
  		• Low-level TOP2A amplification in prostate cancer is associated with HER2 duplication, androgen resistance, and decreased survival
    A. J. Murphy, C. A. Hughes, C. Barrett, H. Magee, B. Loftus, J. J. O'Leary and O. Sheils
    Cancer Res  Vol:67  Issue:6  Pages:2893-8  2007  Mar  Accession No. 17363613
  		• Expression microarray analysis of papillary thyroid carcinoma and benign thyroid tissue: emphasis on the follicular variant and potential markers of malignancy
    S. P. Finn, P. Smyth, S. Cahill, C. Streck, M. O'Regan E, R. Flavin, J. Sherlock, D. Howells, R. Henfrey, M. Cullen, M. Toner, C. Timon, J. O'Leary J and O. M. Sheils
    Virchows Arch  Vol:450  Issue:3  Pages:249-60  2007  Mar  Accession No. 17252232
  		• Heterogeneous expression of alpha-methylacyl-CoA racemase in prostatic cancer correlates with Gleason score
    A. J. Murphy, C. A. Hughes, G. Lannigan, O. Sheils, J. O'Leary and B. Loftus
    Histopathology  Vol:50  Issue:2  Pages:243-51  2007  Jan  Accession No. 17222253
  		• Free fetal DNA is not increased before 20 weeks in intrauterine growth restriction or pre-eclampsia
    A. Crowley, C. Martin, P. Fitzpatrick, O. Sheils, C. O'Herlihy, J. J. O'Leary and B. M. Byrne
    Prenat Diagn  Vol:27  Issue:2  Pages:174-9  2007  Feb  Accession No. 17191257
  		• Effect of ret/PTC 1 rearrangement on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model
    S. Cahill, P. Smyth, S. P. Finn, K. Denning, R. Flavin, E. M. O'Regan, J. Li, A. Potratz, S. M. Guenther, R. Henfrey, J. J. O'Leary and O. Sheils
    Mol Cancer  Vol:5  Pages:70  2006  Jan  Accession No. 17156473
  		• Genome-wide analysis of deoxyribonucleic acid in endometrial cancer using comparative genomic hybridization microarrays
    S. A. O'Toole, E. Dunn, B. L. Sheppard, H. Klocker, J. Bektic, P. Smyth, C. Martin, O. Sheils and J. J. O'Leary
    INT J GYNECOL CANCER  Vol:16  Issue:2  Pages:834-42  2006  Mar  Accession No. 16681770
  		• Distinct array comparative genomic hybridization profiles in oral squamous cell carcinoma occurring in young patients
    M. O'Regan E, M. E. Toner, P. C. Smyth, S. P. Finn, C. Timon, S. Cahill, R. Flavin, J. O'Leary J and O. Sheils
    Head Neck  2006  Feb  Accession No. 16470878
  		• Molecular classification and biomarker discovery in papillary thyroid carcinoma
    O. Sheils
    Expert Rev Mol Diagn  Vol:5  Issue:6  Pages:927-46  2005  Nov  Accession No. 16255634
  		• Squamous cell carcinoma of the head and neck in young Irish adults
    M. O'Regan E, C. Timon, O. Sheils, M. Codd, J. O'Leary J and M. Toner
    Br J Oral Maxillofac Surg  2005  Jul  Accession No. 16005553
  		• Molecular pathology of prostate cancer
    C. Hughes, A. Murphy, C. Martin, O. Sheils and J. O'Leary
    J Clin Pathol  Vol:58  Issue:7  Pages:673-84  2005  Jul  Accession No. 15976331
  		• Analysis of DNA in endometrial cancer cells treated with phyto-estrogenic compounds using comparative genomic hybridisation microarrays
    S. A. O'Toole, B. L. Sheppard, O. Sheils, J. J. O'Leary, B. Spengler and V. Christoffel
    Planta Med  Vol:71  Issue:5  Pages:435-9  2005  May  Accession No. 15931582
  		• Oestrogen regulated gene expression in normal and malignant endometrial tissue
    S. A. O'Toole, E. Dunn, B. L. Sheppard, O. Sheils, J. J. O'Leary, W. Wuttke and D. Seidlova-Wuttke
    Maturitas  Vol:51  Issue:2  Pages:187-98  2005  Jun  Accession No. 15917160
  		• p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer
    N. Murphy, M. Ring, C. C. Heffron, B. King, A. G. Killalea, C. Hughes, C. M. Martin, E. McGuinness, O. Sheils and J. J. O'Leary
    J Clin Pathol  Vol:58  Issue:5  Pages:525-34  2005  May  Accession No. 15858126
  		• Detection of a tyrosine phosphatase LAR on intestinal epithelial cells and intraepithelial lymphocytes in the human duodenum
    A. M. Murphy, O. M. Sheils, G. S. McDonald and D. P. Kelleher
    Mediators Inflamm  Vol:2005  Issue:1  Pages:23-30  2005  Feb  Accession No. 15770063
  		• ret/PTC and BRAF act as distinct molecular, time-dependant triggers in a sporadic Irish cohort of papillary thyroid carcinoma
    P. Smyth, S. Finn, S. Cahill, E. O'Regan, R. Flavin, J. J. O'Leary and O. Sheils
    Int J Surg Pathol  Vol:13  Issue:1  Pages:01-Aug  2005  Jan  Accession No. 15735849
  		• Quantitation of CDC6 and MCM5 mRNA in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix
    N. Murphy, M. Ring, C. C. Heffron, C. M. Martin, E. McGuinness, O. Sheils and J. J. O'Leary
    Mod Pathol  Vol:18  Issue:6  Pages:844-9  2005  Jun  Accession No. 15696126
  		• P16(INK4A) positivity in benign, premalignant and malignant cervical glandular lesions: a potential diagnostic problem
    N. Murphy, C. C. Heffron, B. King, U. G. Ganuguapati, M. Ring, E. McGuinness, O. Sheils and J. J. O'Leary
    Virchows Arch  2004  Sep  Accession No. 15378361
  		• Array comparative genomic hybridisation analysis of gamma-irradiated human thyrocytes
    S. P. Finn, P. Smyth, E. O'Regan, S. Cahill, R. Flavin, J. O'Leary and O. Sheils
    Virchows Arch  2004  Jul  Accession No. 15258756
  		• Real-time analysis of beta- and gamma-catenin mRNA expression in ret/PTC-1 activated and nonactivated thyroid tissues
    P. Smyth, S. Finn, J. O'Leary and O. Sheils
    Diagn Mol Pathol  Vol:12  Issue:1  Pages:44-9  2003  Mar  Accession No. 12605035
  		• Real-time quantitative analysis of E-cadherin expression in ret/PTC-1-activated thyroid neoplasms
    P. Smyth, O. Sheils, S. Finn, C. Martin, J. O'Leary and E. C. Sweeney
    Int J Surg Pathol  Vol:9  Issue:4  Pages:265-72  2001  Oct  Accession No. 12574841
  		• Ret/PTC chimeric transcripts in an Irish cohort of sporadic papillary thyroid carcinoma
    S. P. Finn, P. Smyth, J. O'Leary, E. C. Sweeney and O. Sheils
    J Clin Endocrinol Metab  Vol:88  Issue:2  Pages:938-41  2003  Feb  Accession No. 12574236
  		• p16INK4A as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep smears
    N. Murphy, M. Ring, A. G. Killalea, V. Uhlmann, M. O'Donovan, F. Mulcahy, M. Turner, E. McGuinness, M. Griffin, C. Martin, O. Sheils and J. J. O'Leary
    J Clin Pathol  Vol:56  Issue:1  Pages:56-63  2003  Jan  Accession No. 12499437
  		• Detection of measles virus in children with ileo-colonic lymphoid nodular hyperplasia, enterocolitis and developmental disorder
    C. M. Martin, V. Uhlmann, A. Killalea, O. Sheils and J. J. O'Leary
    Mol Psychiatry  Vol:7 Suppl 2  Pages:S47-8  2002  Jan  Accession No. 12142949
  		• RET/PTC rearrangements in Hashimoto's thyroiditis
    O. Sheils, P. Smyth, S. Finn, E. C. Sweeney and J. J. O'Leary
    Int J Surg Pathol  Vol:10  Issue:2  Pages:167-8; author reply 168-9  2002  Apr  Accession No. 12075413
  		• Potential viral pathogenic mechanism for new variant inflammatory bowel disease
    V. Uhlmann, C. M. Martin, O. Sheils, L. Pilkington, I. Silva, A. Killalea, S. B. Murch, J. Walker-Smith, M. Thomson, A. J. Wakefield and J. J. O'Leary
    Mol Pathol  Vol:55  Issue:2  Pages:84-90  2002  Apr  Accession No. 11950955
  		• ret/PTC-1 Activation in Hashimoto Thyroiditis
    O. M. Sheils, J. O'Eary J, V. Uhlmann, K. Lattich and E. C. Sweeney
    Int J Surg Pathol  Vol:8  Issue:3  Pages:185-189  2000  Jul  Accession No. 11493988
  		• Expression profile of human herpesvirus 8 (HHV-8) in pyothorax associated lymphoma and in effusion lymphoma
    M. O'Donovan, I. Silva, V. Uhlmann, N. Bermingham, K. Luttich, C. Martin, O. Sheils, A. Killalea, C. Kenny, S. Pileri and J. J. O'Leary
    Mol Pathol  Vol:54  Issue:2  Pages:80-5  2001  Apr  Accession No. 11322168
  		• Assessment of ret/PTC-1 rearrangements in neoplastic thyroid tissue using TaqMan RT-PCR
    O. M. Sheils, J. J. O'Leary and E. C. Sweeney
    J Pathol  Vol:192  Issue:1  Pages:32-6  2000  Sep  Accession No. 10951397
  		• Cellular localisation of HHV-8 in Castleman's disease: is there a link with lymph node vascularity?
    J. O'Leary, M. Kennedy, D. Howells, I. Silva, V. Uhlmann, K. Luttich, S. Biddolph, S. Lucas, J. Russell, N. Bermingham, M. O'Donovan, M. Ring, C. Kenny, M. Sweeney, O. Sheils, C. Martin, S. Picton and K. Gatter
    Mol Pathol  Vol:53  Issue:2  Pages:69-76  2000  Apr  Accession No. 10889905
  		• Improved in situ detection method for telomeric tandem repeats in metaphase spreads and interphase nuclei
    V. Uhlmann, M. Prasad, I. Silva, K. Luettich, L. Grande, L. Alonso, M. Thisted, K. J. Pluzek, J. Gorst, M. Ring, M. Sweeney, C. Kenny, C. Martin, J. Russell, N. Bermingham, M. O'Donovan, O. Sheils and J. J. O'Leary
    Mol Pathol  Vol:53  Issue:1  Pages:48-50  2000  Feb  Accession No. 10884922
  		• Localisation of HHV-8 in AIDS related lymphadenopathy
    J. J. O'Leary, M. Kennedy, K. Luttich, V. Uhlmann, I. Silva, J. Russell, O. Sheils, M. Ring, M. Sweeney, C. Kenny, N. Bermingham, C. Martin, M. O'Donovan, D. Howells, S. Picton and S. B. Lucas
    Mol Pathol  Vol:53  Issue:1  Pages:43-7  2000  Feb  Accession No. 10884921
  		• TSH receptor status of thyroid neoplasms--TaqMan RT-PCR analysis of archival material
    O. M. Sheils and E. C. Sweeney
    J Pathol  Vol:188  Issue:1  Pages:87-92  1999  May  Accession No. 10398146
  		• Sorting out mix-ups. The provenance of tissue sections may be confirmed by PCR using microsatellite markers
    D. S. O'Briain, O. Sheils, S. McElwaine, S. R. McCann and M. Lawler
    Am J Clin Pathol  Vol:106  Issue:6  Pages:758-64  1996  Dec  Accession No. 8980351
  		• Colocalisation of human immunodeficiency virus and human cytomegalovirus infection in brain autopsy tissue from AIDS patients
    I. M. Balluz, M. A. Farrell, E. Kay, M. J. Staunton, J. N. Keating, O. Sheils, S. L. Cosby, M. J. Mabruk, B. J. Sheahan and G. J. Atkins
    Ir J Med Sci  Vol:165  Issue:2  Pages:133-8  1996  Apr  Accession No. 8698561
  		• Adenovirus 12 E1A gene detection by polymerase chain reaction in both the normal and coeliac duodenum
    M. Lawler, P. Humphries, C. O'Farrelly, H. Hoey, O. Sheils, M. Jeffers, D. S. O'Briain and D. Kelleher
    Gut  Vol:35  Issue:9  Pages:1226-32  1994  Sep  Accession No. 7959228
  		• Detection of Epstein-Barr virus DNA in tongue tissues from AIDS autopsies without clinical evidence of oral hairy leukoplakia
    M. J. Mabruk, S. R. Flint, M. Toner, N. Leonard, O. Sheils, D. C. Coleman and G. J. Atkins
    J Oral Pathol Med  Vol:24  Issue:3  Pages:109-12  1995  Mar  Accession No. 7776261
  		• Tyrosine phosphorylation in the human duodenum
    D. Kelleher, A. Murphy, O. Sheils, A. Long and J. McDevitt
    Gut  Vol:36  Issue:1  Pages:34-8  1995  Jan  Accession No. 7534252
  		• Effect of cyclosporin on immune complex deposition in murine glomerulonephritis
    D. G. Quinn, J. S. Fennell, O. Sheils, E. F. Gaffney and C. F. Feighery
    Immunology  Vol:72  Issue:4  Pages:550-4  1991  Apr  Accession No. 1828056
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