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DMMC COURSES & WORKSHOPS
POPULATION
GENETICS & SNP ANALYSIS
6 - 7 June 2007
Lecture Sessions: 1330-1745 on Wed, 1400-1745 on Thu.
Practical Workshop: 0900-1300 on Thu.
Venue: Durkin
Theatre, Institute of Molecular Medicine, TCD, St James's Hospital
(location)
Applications
are closed
Online application period: 3 May - 1 June 2007
Download
the workshop poster (750KB PDF)
The
analysis of genetic determinants in human disease, particularly
in multifactorial conditions such as cardiovascular disease, has
advanced markedly in recent years due to the availability of high-density
maps of Single Nucleotide Polymorphism (SNP) markers, new insights
into human genome structure from the International HapMap Project
and novel analytical methods. This course, running over one and
a half days, aims to introduce researchers to key strategic considerations
in designing and performing gene-mapping studies using SNP markers.
It will also provide some ‘hands-on’ experience of data
analysis through a practical workshop.
Please
note: the practical workshop is limited to 25 participants who will
be selected from the course applicants.
Day
1 will focus on the nature and dynamics of SNP markers in populations,
associations between markers due to the haplotype ‘block’
structure of the human genome and public domain resources for gene-mapping
studies. Talks on applying these tools to clinical problems and
the evolution of populations are followed by a Plenary Lecture on
genome wide analysis of copy number variation given by Dr Jonathan
Sebat (Cold Spring Harbor Laboratory, USA).
Day
2 will begin with a ‘hands-on’ practical workshop that
examines resources for selecting SNPs, issues around study design
& power and data management, and will give time for some basic
analyses of SNP data. The day will continue with talks on key aspects
of study design, diagnostic and clinical applications.
Please
note: the schedule is subject to change.
| Wed
6 Jun; 1330-1745 LECTURE SESSION |
| 1330 |
Introduction
to SNPs
Prof
David Croke (RCSI) abstract |
| 1400 |
Overview
of Resources
Dr
Ross McManus (TCD) |
| 1430 |
Introduction
to Study Design
Prof
Denis Shields (UCD) |
| 1500 |
Plenary
Lecture I
Genome wide association study in coeliac disease.
Prof David van Heel (Queen Mary's School of Medicine and Dentistry)
abstract
|
| 1540 |
Coffee/Tea |
| 1610 |
Structure
& Selection in the Irish Population Prof Dan Bradley
(TCD) abstract |
| 1700 |
The
Genetic Architecture of Atopic Dermatitis
Dr
Alan Irvine (TCD)
|
| Thu
7 Jun; 0900-1300 PRACTICAL WORKSHOP |
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Lead
Instructor: Dr Ross McManus (TCD)
Topics
to be covered include: |
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Generating
haplotypes
Tagging SNPs
Association analysis
Data management
Basic statistical analysis |
| Thu
7 Jun; 1400-1745 LECTURE
SESSION |
| 1400 |
Study
Design & Sample Size
Prof
Denis Shields (UCD) |
| 1445 |
PharmacoGenetics/Omics
of Cardiovascular Disease
Dr Alice Stanton (RCSI) abstract |
| 1540 |
Coffee/Tea |
| 1610 |
Diagnostic
Applications of SNP typing
Dr David Barton (National Centre for Medical Genetics
& UCD) abstract |
| 1700 |
Plenary
Lecture II
Genome-Wide
Analysis of Copy Number Variation in Autism
Dr
Jonathan Sebat (Cold Spring Harbor Laboratory, NY, USA) abstract
An HRB/IMM Genes and Environment Programme
Presentation |
Course
Coordinators
Prof
David Croke (Molecular & Cellular Therapeutics, RCSI)
Dr
Ross McManus (Institute of Molecular Medicine, St James's Hospital,
TCD)
Prof
Denis Shields (UCD Conway Institute of Biomolecular & Biomedical
Research)
Course
Instructors
Prof
Dan Bradley (Smurfit Institute of Genetics, TCD)
Dr
David Barton (National Centre for Medicial Genetics, Our Lady's
Hospital for Sick Children, Dublin & UCD)
Dr
Alan Irvine
(Our Lady's Hospital for Sick Children, Dublin & TCD)
Dr
Derek Morris (Institute of Molecular Medicine, St James's Hospital,
TCD)
Dr
Tony Ryan (Institute of Molecular Medicine, St James's Hospital,
TCD)
Dr
Alice Stanton (RCSI Research Institute and Molecular & Cellular
Therapeutics, RCSI)
Course
Sponsors
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