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DMMC COURSES & WORKSHOPS
MODEL
SYSTEMS IN BIOMEDICAL RESEARCH: SCIENTIFIC BREAKTHROUGHS
23 & 30 March, 27 April and 4, 11 & 18 May 2006
(1000-1300 Thursdays)
Venue: Seminar
Room 2, UCD Conway Institute of Biomolecular & Biomedical Research
(location)
Online
application is closed
Online application period: 20 Feb - 13 Mar 2006
Application
for this course is open to postgraduate
students and staff at TCD, UCD, RCSI and affiliated hospitals. Those
interested in attending who are based outside these institutions
should contact education@dmmc.ie
before applying online.
Model
organisms are tractable experimental systems used in scientific
research to provide information about more complex species, including
humans, that are more difficult to study directly. Because fundamental
biological pathways and the proteins that execute them have been
highly conserved throughout evolution, model organisms have provided
significant insight into the basic properties of all living cells.
Model organism research is therefore relevant to human biology,
and numerous experimental models of human disease have been established.
This
course aims to demonstrate the power of model experimental systems
in biomedical research by highlighting examples of major scientific
breakthroughs achieved in various model organisms. The course brings
together Irish and international experts who utilise model experimental
systems in their own research. The model systems to be discussed
are:
- Monkey
virus SV40
- Nematode
Caenorhabditis elegans
- Mustard
plant Arabidopsis thaliana
- Brewer’s
yeast Saccharomyces cerevisiae
- African
clawed frog Xenopus laevis
- Zebrafish
Danio rerio
- House
mouse Mus musculus
- Fruit
fly Drosophila melanogaster
- Canine
Canis familiaris
Since
model organisms have been indispensable in the development of innovative
methodologies and technologies, each lecture will also include a
Technical Spotlight that describes a powerful experimental
tool developed in the model system.
Follow
the links below to read an abstract of each lecture, and access
supplementary resources. Abstracts will appear as soon as we receive
them.
Thu
23 Mar; 1000-1300
1000 Course introduction & overview
Dr Rosemary
Clyne, UCD resources
1030 Comparative Genomics Prof Ken Wolfe,
TCD
abstract
1115 Coffee/Tea
1145 Simian virus 40 (SV40): DNA replication
Technical
Spotlight: restriction endonucleases
Dr Rosemary
Clyne, UCD abstract
Thu
30 Mar; 1000-1300
1000
Caenorhabditis
elegans:
apoptosis
Technical
Spotlight: RNAi
Prof Michael
Hengartner, University of Zurich
abstract
1115 Coffee/Tea
1145 Arabidopsis thaliana:
eukaryotic genetics and
functional genomics
Technical
Spotlight: knock-out and gene/enhancer
trap lines
Dr Charles
Spillane, University College Cork
abstract
Thu
27 Apr; 1000-1300
1000
Yeast: prion research
Technical
Spotlight: infecting yeast with prions
Dr Gary Jones,
NUI Maynooth abstract
1115 Coffee/Tea
1145 Yeast: the cell cycle
Technical
Spotlight: conditional mutagenesis
Prof Noel
Lowndes, NUI Galway abstract
Thu
4 May; 1000-1300
1000
Xenopus laevis: using eggs and embryos for
cell cycle research
Technical
Spotlight: cell cycle extracts
Claire Moran
(UCD Xenopus Biology Group headed
by Dr Carmel Hensey) abstract
1115 Coffee/Tea
1145 Zebrafish: models of human disease
Technical
Spotlight: morpholinos
Dr
Lucy Byrnes, NUI Galway abstract
Thu
11 May; 1000-1300
1000
Mouse: transgenic and knockout mice in prion
research
Technical
Spotlight: transgenic mouse production
Dr Mike Scott,
UCD abstract
1115 Coffee/Tea
1145 Mouse: knock-out technology and NSAID drug
development
Technical
Spotlight: targeted disruption of
cyclooxygenases
1 and 2
Dr Sandra
Austin, UCD abstract
Thu
18 May; 1000-1300
1000
Drosophila: probing nervous system function
using behavioural
genetics
Technical
Spotlight: P-element mediated gene
engineering and
mutagenesis
Prof Robert
Reenan, University of Connecticut
Health Centre abstract
1115 Coffee/Tea
1145 Canis familiaris: the pathophysiology of
narcolepsy
Technical
Spotlight: mapping of common and
complex disorders:
the canine potential
Dr Kay Nolan,
UCD abstract
Course
Coordinator
Dr
Rosemary Clyne (UCD Conway Institute of Biomolecular and Biomedical
Research)
Course
Instructors
Dr
Sandra Austin
(UCD Conway Institute of Biomolecular and Biomedical Research)
Dr
Lucy Byrnes (Department of Biochemistry, National University
of Ireland, Galway)
Prof
Michael Hengartner (Institute of Molecular Biology, University
of Zurich, Switzerland)
Dr
Carmel Hensey
(UCD Conway Institute of Biomolecular and Biomedical Research)
Dr
Gary Jones (Department of Biology, National University of Ireland,
Maynooth)
Prof
Noel Lowndes (Department of Biochemistry, National University
of Ireland, Galway)
Dr
Kay Nolan (School of Biological and Environmental Science, UCD)
Prof
Robert Reenan (University of Connecticut Health Centre, USA)
Dr
Mike Scott (UCD
Conway Institute of Biomolecular and Biomedical Research)
Dr
Charles Spillane (Department of Biochemistry,
University College Cork)
Prof Ken Wolfe
(Smurfit Institute of Genetics, TCD) |
