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DMMC COURSES & WORKSHOPS

IMMUNOBIOLOGY
10 Jan - 7 Mar 2007; 1015-1245 weekly (Wed)
Venue: Education & Research Centre, St Vincent's University Hospital, Dublin 4 (location)

Applications are now closed
Online application period was:
27 Nov - 22 Dec 2006

The aim of this course is to introduce students to the basic concepts and terminology required to understand immunology. At the end of the course, participants should be familiar with the terms and models of innate and adaptive immunity and be conversant with the names and functions of the organs, cells, molecules and genes involved in initiating and mediating immune responses. Participants should be able to explain fundamental immunological concepts and discuss the roles of key components of the immune system including acute phase proteins, complement, haematopoietic cells, immunoglobulins and cytokines in protecting against disease. The course will also provide an understanding of some basic concepts of immunological dysregulation seen in inflammatory and autoimmune diseases, allergy, malignancy and immunopathogenesis and appreciate genomic influences on these processes.

Wed 10 Jan; 1015-1245
Introductory overview Prof Cliona O'Farrelly, UCD
Organs, cells, molecules and genes of the immune system; introduction to innate immunity
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Wed 17 Jan; 1015-1245
Innate immunity I Dr John Baugh, UCD
Toll like receptors; anti-microbial peptides; complement
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Wed 24 Jan; 1015-1245
Innate immunity II Dr John Baugh, UCD
Inflammation; cytokines; anti-inflammatory mechanisms
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Wed 31 Jan; 1015-1245
Linking innate and adaptive immunity
Prof Cliona O'Farrelly, UCD ?
Cytokines; chemokines; Dendritic cells (DCs); Natural Killer cells (NK); introduction to adaptive immunity
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Wed 7 Feb; 1015-1245
Antigen processing and presentation
Dr Elizabeth Ryan, St. Vincent's University Hospital
Major Histocompatability Complex (MHC); class I; class II
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Wed 14 Feb; 1015-1245
Cellular and molecular components of adaptive immunity I Prof Cliona O'Farrelly, UCD
T cells; CD3; CD4; CD8; TCR; T cell activation; T cell development
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Wed 21 Feb; 1015-1245
Cellular and molecular components of adaptive immunity II
Prof Cliona O'Farrelly, UCD
B cells; antibodies IgM; IgD; IgG; IgA; Ige; allergy
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Wed 28 Feb; 1015-1245
Effector mechanisms in immunology
Dr Elizabeth Ryan, St. Vincent's University Hospital
How the immune system protects against infection (phagocytosis; opsonisation; cytotoxicity; apoptosis; NK cell activity; cell killing; C' activation); vaccination
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Wed 7 Mar; 1015-1245

Immunological dysregulation and intervention
Prof Cliona O'Farrelly, UCD
Dr Jean Fletcher, TCD
Dr Doug Veale, St. Vincent's University Hospital

Autoimmunity - Rheumatoid Arthritis and Multiple Sclerosis; mechanisms of disease; immunogenomics; immunotherapy

Recommended Text
Immunobiology (6th Ed). C.A. Janeway, P. Travers, M. Walport, M. Shlomchik (Garland / Churchill Livingstone).
The previous edition is accessible in the Bookshelf section of the NCBI website

Course Leader
Prof Cliona O'Farrelly

Education & Research Centre,
St. Vincent's University Hospital
Email: cliona.ofarrelly@ucd.ie

Contributors
Dr Elizabeth Ryan (St. Vincent's University Hospital)
Dr John Baugh (UCD Conway Institute of Biomolecular & Biomedical Science)
Dr Jean Fletcher (School of Biochemistry & Immunology, TCD)
Dr Doug Veale (St. Vincent's University Hospital)

      

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