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DMMC COURSES & WORKSHOPS

IMMUNOBIOLOGY
2 Feb - 23 Mar 2005; 1400-1600 weekly (Wed)
Venue: Education & Research Centre, St Vincent's University Hospital (location)

Wed 2 Feb 2005; 1400-1600, Seminar Room
Introductory Overview
Organs, cells and molecules of the immune system.

Wed 9 Feb 2005; 1400-1600, Lecture Hall
Innate Immunity 1
Toll like receptors; cytokines; chemokines; anti-microbial peptides.

Wed 16 Feb 2005; 1400-1600, Lecture Hall
Innate Immunity 2
Complement; inflammation; anti-inflammatory mechanisms.

Wed 23 Feb 2005; 1400-1600, Seminar Room
Major Histocompatibility Complex
Antigen processing and presentation; dendritic cell maturation.

Wed 2 Mar 2005; 1400-1600, Seminar Room
Cellular and Molecular Components of Adaptive Immunity
T and B lymphocytes; TCR; immunoglobulins; regulatory cytokines.

Wed 9 Mar 2005; 1400-1600, Seminar Room
Lymphocyte Development
Haematopoietic stem cells; thymus; bone marrow; gene rearrangement; positive and negative thymic selection.

Wed 16 Mar 2005; 1400-1600, Lecture Hall
Effector Mechanisms in Immunology
Cytotoxicity; apoptosis; immune responses to pathogenic challenge; tolerance induction.

Wed 23 Mar 2005; 1400-1600, Lecture Hall
Immunological Dysregulation
Malignancy, autoimmunity and allergy.

Objectives of the course
At the end of this course, participants should be familiar with the basic terms and concepts of innate and adaptive immunity and will hopefully be conversant with the names and functions of the main organs, cells, molecules and genes involved in initiating and mediating immune responses. They should be able to explain fundamental immunological concepts and discuss the roles of functional components of the immune system including acute phase proteins, complement, haematopoietic cells, immunoglobulins and cytokines in protecting against disease. They should also understand some basic concepts of immunological dysregulation seen in inflammatory and autoimmune diseases, allergy, malignancy and immunopathogenesis.

Recommended text
Immunobiology (6th ed). C.A. Janeway, P. Travers, M. Walport, M. Shlomchik (Garland / Churchill Livingstone).
The previous edition is accessible in the Bookshelf section of the NCBI website

Course leader
Prof Cliona O’Farrelly
Education & Research Centre
St.Vincent’s University Hospital
e.mail: cliona.ofarrelly@ucd.ie

Contributors
Dr Lucy Golden-Mason (SVUH)
Dr John Baugh (Dept of Medicine, UCD)