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DMMC COURSES & WORKSHOPS
DRUG
DESIGN: PRINCIPLES & TECHNIQUES
10, 11, 20 & 21 April 2006 (1330-1700 on 10, 11 &
20 April; 0930-1300 on 21 April)
Venue: Albert
Lecture Theatre, The Royal College of Surgeons in Ireland (location)
Online
application is closed
Online application period: 27 Feb - 27 Mar 2006
Application
for this course is open to postgraduate
students and staff at RCSI, UCD, TCD and affiliated hospitals. Those
interested in attending who are based outside these institutions
should contact education@dmmc.ie
before applying online.
This
course is designed to give clinicians and researchers from the life,
chemical and physical sciences a broad overview of the concepts,
strategies and research techniques used in drug discovery. Basic
understanding of molecular structures is assumed, but you should
not need prior knowledge of the models and techniques covered in
the course.
The
objective for postgraduate teaching is to give students an overview
and illustrations of how proteins and other biologically active
molecules, targeted by or identified in laboratory research (in
silico or in vitro), can be studied to develop chemical
agents mimicking or interacting with them. This process can ultimately
lead to the development of new therapeutic candidates. We recommend
that postgraduate students attend the whole course (DMMC Course
Attendance Certificates are only provided for complete attendance).
Follow
the links below to read an abstract of each lecture, together with
supplementary reading.
Mon
10 Apr; 1330-1700
1330 History of drug discovery Dr Marc
Devocelle,
RCSI
abstract
1415 Molecular basis of drug action: drug receptor
interactions
Dr Isabel Rozas, TCD abstract
1500 Coffee/Tea
1530 Molecular basis of drug action: catalytic
receptors, enzymes
and their inhibition
Dr John Gilmer,
TCD abstract
1615 Natural products as leads in drug design
Dr James Barlow,
RCSI abstract
Tue
11 Apr; 1330-1700
1330
Peptidomimetic design
Dr Marc Devocelle,
RCSI abstract
1415 Synthetic molecules as drugs: macromolecules
Dr Rafe Darcy,
UCD abstract
1500 Coffee/Tea
1530 The role of drug delivery in drug design and
drug development
Dr Sally-Ann Cryan, RCSI
abstract
1615 Drug delivery: from molecular packaging to
targeting
Dr Rafe Darcy, UCD abstract
Thu
20 Apr; 1330-1700
1330
The concept of pharmacophore: biological
perspective
Dr Niamh Moran, RCSI
Due to unavoidable
circumstances Dr Moran was
unable to present.
Dr Sarah O'Neill (RCSI)
presented the lecture.
1415 The concept of pharmacophore: informatics
perspective
Prof Denis Shields, UCD abstract
1500 Coffee/Tea
1530 Rational drug design: structure/activity
relationships
Dr Isabel Rozas, TCD abstract
1615 Rational drug design: computer-aided drug
design
Dr Darren Fayne, TCD abstract
Fri
21 Apr; 0930-1300
0930
Techniques in rational drug design: X-ray
crystallography
& NMR Dr Amir Khan, TCD
abstract
1015 Synthetic molecules as drugs: small molecules
Dr Mahmood
Ahmed, GlaxoSmithKline
supplementary
reading
1100 Coffee/Tea
1130 IP issues in drug design Mr Barry Purdy, Purdy
&
Company
abstract
1215 Case studies in drug discovery and design
Dr Mary
Meegan, TCD abstract
Course
Coordinator
Dr
Marc Devocelle (Department of Pharmaceutical Chemistry, RCSI)
Course
Instructors
Dr
Mahmood Ahmed (Neurological and GI Centre for Excellence in Drug
Discovery (N&GI
CEDD), GlaxoSmithKline,
Harlow UK)
Dr
James Barlow
(School of Pharmacy, RCSI)
Dr
Sally-Ann Cryan (School of Pharmacy, RCSI)
Dr
Rafe Darcy
(UCD School of Chemistry & Chemical Biology and Conway Institute)
Dr
Darren Fayne (Molecular
Design Group, School
of Biochemistry and Immunology,
TCD)
Dr
John Gilmer (School of Pharmacy & Pharmaceutical Sciences,
TCD)
Dr
Amir Khan (School of Biochemistry and Immunology, TCD)
Dr
Mary Meegan (School of Pharmacy & Pharmaceutical Sciences,
TCD)
Dr
Niamh Moran (Department of Clinical Pharmacology, RCSI)
Mr
Barry Purdy (European Patent Attorney, Purdy
& Company)
Dr
Isabel Rozas (School of Chemistry, TCD)
Prof
Denis Shields (UCD Conway Institute of Biomolecular & Biomedical
Research)
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