DMMC Course: MOLECULAR CELL BIOLOGY IN ACTION

1110-1230 Monday 17 January 2005. Conway Institute Lecture Theatre, UCD

Transcription regulation Dr Leonie Young, UCD

The mechanism that controls transcriptional activity is an intensely investigated and continuously evolving field of research. Transcriptional regulation is dependent, not only on transcription factor activation and chromatin remodelling, but also on a host of transcription factor co-regulators; co-activators and co-repressors. In addition there is a growing array of modifications that can direct transcriptional activity in a cell and promoter specific fashion. In this lecture we will deal with transcription factors, in particular, nuclear receptors, interactions with co-regulatory proteins and subsequent chromatin remodelling. These principles will be illustrated by looking at specific research into transcription factor - co-regulatory protein interactions in endocrine resistant breast cancer.