DMMC Course: MOLECULAR CELL BIOLOGY IN ACTION

0930-1050 Monday 14 February 2005. Conway Institute Lecture Theatre, UCD

Insulin receptor tyrosine kinase signalling: from molecules to mice
Dr Derek Brazil, UCD

An overview of tyrosine kinase receptor signaling, with specific emphasis on insulin receptor signaling pathways. Scaffold/adaptor proteins typified by insulin receptor substrate (IRS) proteins and their role in signal transduction. PI3Kinase signaling, with particular focus on Protein kinase B (PKB/Akt) signaling. Elements of personal research to be discussed will include the role of IRS-2 in physiology and diabetes, mouse models in diabetes research, and the function of PKB/Akt in diabetes and cancer.