DMMC Course MODEL SYSTEMS IN BIOMEDICAL RESEARCH: SCIENTIFIC BREAKTHROUGHS

1145-1300 Thursday 11 May 2006. UCD Conway Institute Seminar Room 2

Mouse: knock-out technology and NSAID drug development
Technical Spotlight: targeted disruption of Cyclooxygenases 1 and 2
Dr Sandra Austin (UCD Conway Institute of Biomolecular and Biomedical Research)

Recent controversies surrounding the COX2 inhibitor VIOXX emphasise how far we have yet to go in our search for the ideal anti-inflammatory drug. This lecture describes the use of reverse genetic studies to both identify new drug targets and inform development of novel drugs.